季文治 理学博士，研究员，助理教授，博士生导师

电子邮箱: jiwz@bjmu.edu.cn

教育经历

2009-2013 北京大学化学与分子工程学院 学士

2013-2018 清华大学药学院 博士

研究经历

2018-2020 普渡大学药学院 博士后

2020-2026 斯坦福大学癌症研究所 博士后&研究科学家

2026-今 北京大学药学院 助理教授

研究方向： 药物化学 药物设计 药物合成

1)  新型诱导邻近药物模式设计与药物开发：探索开发新型诱导邻近（Induced Proximity）作用模式，并基于TCIP、RIPTAC、Molecular Glue、PROTAC等新兴概念，开展靶向传统意义上的具有挑战性的药物靶点。

2)  新型共价药物设计与开发：围绕新型共价活性官能团设计，结合分子文库、化学蛋白组学与基于结构的药物设计等方法，开发具有高选择性、低毒性的新型共价药物。

3)  新模式药物的创新合成方法与合成路径设计：针对新型药物作用模式的分子结构需求，开发高效、简洁、可规模化制备的创新合成技术与工艺路径。

论文发表

1. L. Yuan*, W. Ji*, B.G. Dwyer*, J. Lu, J. Bian, G.M. Colombo, M.J. Martinez, D. Fernandez, N.A. Phillips, M.T. Tang, C.W. Zhou, N. Quispe Calla, C. Guzman Huancas, M. Eckart, J. Tran, H.M. Jones, T. Qiu, J.G. Doench, M.G. Rees, J.A. Roth, M.D. Cameron, G.W. Charville, C.J. Kuo, S.J. Dixon, T. Zhang, S.M. Hinshaw, N.S. Gray, S.M. Corsello. Defining the Antitumor Mechanism of Action of a Clinical-Stage Compound as a Selective Degrader of the Nuclear Pore Complex. Cancer Discovery. 2025, 15,2505-2529 (*Co-first author)

2. W. Ji, G. Du, J. Jiang, W. Lu, C. E. Mills, L. Yuan, F. Jiang, Z. He, G. A. Bradshaw, M. Chung, Z. Jiang, W. S. Byun, S. M. Hinshaw, T. Zhang, N. S. Gray. Discovery of bivalent small molecule degraders of cyclin-dependent kinase 7 (CDK7) Eur. J. Med. Chem. 2024, 276, 116613.

3. S. Gourisankar*, A. Krokhotin*, W. Ji*, X. Liu, C. Chang, S. H. Kim, Z. Li, W. Wenderski, J. M. Simanauskaite, T. Zhang, N. S. Gray, G. R. Crabtree. Rewiring Cancer Drivers to Activate Apoptosis. Nature, 2023,620, 417-425. (*Co-first author)

4. W. Ji*, W. S. Byun*, W. Lu, K. A. Donovan, J. Tse. E. S. Fischer, T. Zhang, N. S. Gray. Proteomics-Based Discovery of First-in-Class Chemical Probes for Programmed Cell Death Protein 2 (PDCD2) Angew. Chem. Int. Ed. 2023, 62, e2023082. . (*Co-first authors)

5. W. Ji*, E.S. Wang*, T. D. Manz*, J. Jiang*, K. A. Donovan, X. Abulaiti, E. S. Fischer, L. C. Cantley, T. Zhang, N. S. Gray. Development of potent and selective degraders of PI5P4Kγ. Eur. J. Med. Chem. 2023, 247, 115027. (*Co-first authors)

6. N. Darabedian*, W. Ji*, M. Fan, S. Lin, H. Seo, E. Vinogradova, T. Yaron, E. Mills, H. Xiao, K. Senkane, E. Huntsman, J. Johnson, J. Che, L. Cantley. B. Cravatt, S. Dhe-Paganon, K. Stegmaier, T. Zhang, N. S. Gray. E. Chouchani. Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor. Nat. Chem. Biol. 2023, 19,815-824. (*Co-first authors)

7. W. Lu*, M. Fan*, W. Ji*, J. Tse, J. Che, A. Y. Kim, X. Zhu, A. S. Boghossian, M. G. Rees, M. M. Ronan, J. A. Roth, B. Nabet, S. M. Corsello, N. Kwiatkowski, T. Zhang, N. S. Gray. Structure-based Design of Y-shaped Covalent TEAD Inhibitors. J. Med. Chem. 2023. 2023, 66, 7, 4617–4632 (*Co-first authors)

8. W. Ji *, C. Li*, H. Chen, Z. Yu, X. Liao. A newly designed heterodiene and its application to construct six-membered heterocycles containing an N–O bond. Chem. Commun. 2019, 55, 12012−12015. (*Co-first authors)

9. C. Zhang*, W. Ji*, Y.A. Liu, C. Song, X. Liao. Total synthesis of (±)-minfiensine via a formal [3+2] cycloaddition. J. Nat. Prod. 2018. 81, 1065−1069. (*Co-first authors)

10. W. Ji, Y. A. Liu, X. Liao. Transition-metal-free synthesis of N-hydroxy oxindoles by an Aza-Nazarov-Type reaction involving Azaoxyallyl cations. Angew. Chem. Int. Ed. 2016, 55, 13286−13289.

11. W. Ji, L. Yao, X. Liao. Access to the pyrroloindoline core via [3 + 2] annulation as well as the application in the synthetic approach to (±)-Minfiensine. Org. Lett. 2016, 18, 628−630.

12. Z. Li, M. Martinez, W.S. Byun, A.Thathireddy, T. Qiu, Y. Wang, L. Katzengruber, A. Chouldjian, W. Lu, W. Ji, J. Che, T. Zhang, S. M. Hinshaw, N. S. Gray. An AKR1C3-activated kinase inhibitor prodrug RSC Chem. Biol., 2026, 7, 423-432.

13. S.M. Hinshaw, L. Yuan, M.A. Al Noman⁺, M.J. Martinez, G.M. Colombo, B.G. Dwyer, W. Ji, B.A. Romero, I. Forrest, J. Lu, J. Bian, T.B. Dunn, E.R. Garvin, D. Fernandez, T. Zhang, N.S. Gray, S.M. Corsello. The structural basis for nuclear pore destruction by a proximity-inducing molecular glue. Cell Chemical Biology. 2026, 33(6), 799-809.

14. W. Lu, Y. Liu, Y. Gao, Q. Geng, D. Gurbani, L. Li, S. B. Ficarro, C. J. Meyer, I. You, J. Tse, Z, He, W. Ji, J. Che, A. Y. Kim, T. Yu, K. Wen, K. C. Anderson, J. A. Marto, K. D. Westover, T. Zhang, N. S. Gray. Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1. J. Med. Chem. 2023. doi.org/10.1021/acs.jmedchem.2c01834

15. M. Fan, W. Lu, J. Che, N. P. Kwiatkowski, Y. Gao, H. Seo, S. B. Ficarro, P. G. Gokhale, Y. Liu, E. A. Geffken, J. Lakhani, K. Song, M. Kuljanin, W. Ji, J. Jiang, Z. He, J. Tse, A. S. Boghossian, M. G. Rees, M. M. Ronan, J. A. Roth, J. D. Mancias, J. A. Marto, S. Dhe-Pagnon, T. Zhang, N. S. Gray. Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling. eLife 2022, 11, e78810.

16. H. Chen, L. Hu, W. Ji, Y. Li, X. Liao. Nickel-catalyzed decarboxylative alkylation of aryl iodides with anhydrides. ACS Catal. 2018, 8, 10479−10485.

17. T. Xia, Z. Hu, W. Ji, S. Zhang, H. Shi, C. Liu, B. Pang, G. Liu, X. Liao. Synthesis of Withasomnine and pyrazole derivatives via intramolecular dehydrogenative cyclization, as well as biological evaluation of Withasomnine-based scaffolds. Org. Chem. Front. 2018, 5, 850−854.

18. G. Wu, X. Zhao, W. Ji, Y. Zhang, J. Wang, Metal-free oxidative cross-coupling of diazirines with arylboronic acids. Chem. Commun. 2016, 52, 1961−1963.

19. G. Wu, S. Xu, Y. Deng, C, Wu, X. Zhao, W. Ji, Y. Zhang, J. Wang. Coupling of arylboronic acids with benzyl halides or mesylates without adding transition metal catalysts. Tetrahedron 2016, 72, 8022−8030.

20. Z. Shu, W. Ji, X. Wang, Y. Zhou, Y. Zhang, J, Wang. Fe(II)-catalyzed direct cyanation of arenes with aryl(cyano)iodonium triflate. Angew. Chem. Int. Ed. 2014, 53, 2186−2189.