邮箱：niuyouhong@bjmu.edu.cn 电话：010-82805669
教育背景与工作经历
2013/12-至今,北大药学院药物化学系，助理研究员、副研究员
2010/04-2013/07,南佛罗里达大学化学系，药物化学，博士后
2008/09-2010/03,保诺(北京)科技有限公司，项目组长
2004/09-2008/07,兰州大学，有机化学博士学位，导师：叶新山、曹小平教授
2001/09-2004/07,兰州大学，有机化学硕士学位，导师：曹小平、叶新山教授
1997/09-2001/07,武汉工程大学，药物制剂，工学学士
研究方向
基于糖和肽模拟物的化学生物学和药物研究, 杂糖的合成及生物功能研究；免疫抑制剂、抗肿瘤药及糖疫苗发现、新型抗菌、抗结核药物发现；糖肽组装及功能研究。
科研项目
1) 2025.01-2028.12, 国家自然基金面上项目, 项目负责人
2) 2023.12-2026.11，国家重点研发计划项目，主要参与人
3) 2020.01-2023.12, 国家自然基金面上项目，项目负责人
4) 2016.01-2017.12, 国家自然基金面上项目，项目负责人
5) 2016.11-2016.12, 药学院青年培育基金.项目负责人
研究成果
[19] Yang-He Wang#, You-Hong Niu#, Qin Li, Xin-Shan Ye. Angew. Chem. Int. Ed. 2025, e20547
[18] Li-Na Wang #, You-Hong Niu # , Qing-Hui Cai, Qin Li*, Xin-Shan Y. Tetrahedron 2021, 82, 131955.
[17] 李 涛，牛有红∗ ，叶新山∗ . Recent advances on non-peptide or small molecule mimics of antimicrobial peptide. Chinese Journal of Medicinal Chemistry, 2020, 30(30),159.
[16] Youhong Niu,* Minghui Wang, Yafei Cao, Alekhya Nimmagadda, Jianxing Hu, Yanfen Wu, Jianfeng Cai,* Xin-Shan Ye.* Rational Design of Dimeric Lysine N-Alkylamides as Potent and Broad-Spectrum Antibacterial Agents. J. Med. Chem. 2018, 61, 2865−2874.
[15] Shuo Zhang#, You-Hong Niu#, and Xin-Shan Ye. General Approach to Five-Membered Nitrogen Heteroaryl C-Glycosides Using a Palladium/Copper Cocatalyzed C−H Functionalization Strategy. Org. Lett. 2017, 19, 3608−3611.
[14] Minglong Liu#, Youhong Niu#, Yan-Fen Wu, and Xin-Shan Ye. Ligand-Controlled Monoselective C-Aryl Glycoside Synthesis via Palladium-Catalyzed C−H Functionalization of N-Quinolyl Benzamides with 1‑Iodoglycals. Org. Lett. 2016,18, 1836.
[13] Nana Zeng#, Youhong Niu#, Xin-Shan Ye. 3-Butenyloxycarbonyl as a new hydroxyl protecting group in carbohydrate synthesis. Tetrahedron Lett. 2016, 57, 2935–2938.
[12] Haifeng Wang#, Youhong Niu#, Guoying Zhang, Xin-Shan Ye. A unified synthesis of cyclic ethers or lactones via Pd-catalyzed intramolecular O-functionalization of sp3 C-H bonds. Tetrahedron Lett. 2016, 57, 4544
[11] Xiaohui Bai, Youhong Niu#, Jingjing Zhu, An-Qi Yang, Yan-Fen Wu, Xin-Shan Ye. A new GLP-1 analogue with prolonged glucose-lowering activity in vivo via backbone-based modification at the N-terminus. Bioorg. Med. Chem. 2016, 24, 1163.
[10] Wenming Li, Youhong Niu, De-Cai Xiong, Xiaoping Cao, Xin-Shan Ye. Highly Substituted Cyclopentane−CMP Conjugates as Potent Sialyltransferase Inhibitors. J. Med. Chem. 2015, 58, 7972.
[9] Youhong Niu, Haifan Wu, Yaqiong Li, Yaogang Hu, Shruti Padhee, Qi Li, Chuanhai Cao and Jianfeng Cai.* AApeptides as a new class of antimicrobial agents. Org. Biomol. Chem. 2013, 11, 4283-4290.
[8] Youhong Niu, Haifan Wu, Rongfu Huang, QiaoQiao, Frankie Costanza, Xi-Sen Wang, Yaogang Hu, Mohamad Nassir Amin, Anh-My Nguyen, James Zhang, Edward Haller, Shengqian Ma, Xiao Li, and JianfengCai*. Nanorods formed from a new class of peptidomimetics. Macromolecules, 2012, 45, 7350.
[7] Youhong Niu, Rongsheng E. Wang, Haifan Wu, Jianfeng Cai*. Recent development of small antimicrobial peptidomimetics. Future Med. Chem. 2012, 4(14), 1853.
[6] Youhong Niu, Shruti Padhee, Haifan Wu, Ge Bai, QiaoQiao, Yaogang Hu, Lacey Harrington, Whittney N. Burda, Lindsey N. Shaw, Chuanhai Cao, and Jianfeng Cai*. Lipo-γ-AApeptides as a new class of potent and broad-spectrum antimicrobial agents. J. Med. Chem.2012, 55(8), 4003.
[5] Youhong Niu, Ge Bai, Haifan Wu, Rongsheng E. Wang, QiaoQiao, Shruti Padhee, Robert Buzzeo, Chuanhai Cao*, and Jianfeng Cai*. Cellular translocation of a γ-AApeptide mimetic of Tat peptide. Mol. Pharmaceutics.2012, 9, 1529.
[4] Yunan Yang#, Youhong Niu#, Hao Hong, Haifan Wu, Yin Zhang, Jonathan W. Engle, Todd E. Barnhart, Jianfeng Cai*, and Weibo Cai*. Radiolabeled γ-AApeptides: A New Class of Tracers for Positron Emission Tomography. Chem. Commun.2012, 48, 7850.
[3] Youhong Niu, Shruti Padhee, Haifan Wu, Ge Bai, Lacey Harrington, Whitney N. Burda, Lindsey N. Shaw, Chuanhai Cao, and Jianfeng Cai*. Identification of γ-AApeptides with potent and broad-spectrum antimicrobial activity. Chem. Commun. 2011, 47 (44), 12197.
[2] Youhong Niu, Alisha “Jonesy” Jones, Haifan Wu, Gabriele Varani,* and Jianfeng Cai.* γ-AApeptides bind to RNA by mimicking RNA-binding proteins. Org. Biomol. Chem. 2011, 9 (19), 6604.
[1] Youhong Niu, Yaogang Hu, Xiaolong Li, Jiandong Chen, and Jianfeng Cai*.Gamma-AApeptides: Design, Synthesis and Evaluation New J.Chem.2011, 35, 542.
Patents
1. 牛有红，叶新山、吴艳芬、曹亚飞，一种对二苯甲酰二聚体衍生物及其合成方法和应用。201810070032.7, 01/24/2018
2. Jianfeng Cai*, Youhong Niu, Weibo Cai, and Hao Hong. RGD mimetic γ-AApeptides and methods of use. 2012, Application No. 61/667035.
3. Jianfeng Cai*, Youhong Niu, Haifan Wu, Shruti Padhee. “Identification of γ-AApeptides with potent and broad-spectrum antimicrobial activity.”2012, Application No. 61589406.
BOOK CHAPTERS
1. Chapter 4《Antidiabetic drugs based on sodiumglucose cotransporter 2 inhibitor》2024
2《药物化学与药物研发案例》第四章《基于钠-葡萄糖协同转运体(SGLT2)抑制剂开发的抗糖尿病药物》2022.
3. Youhong Niu, Yaogang Hu, Haifan Wu, and Jianfeng Cai*. Synthesis of AApeptides. Link. Peptide Modifications to Increase Metabolic Stability and Activity, 2013, ISBN: 978-1-62703-651-1.
4. Youhong Niu, Yaogang Hu, Rongsheng E. Wang, Xiaolong Li, Haifan Wu, Jiandong Chen* and Jianfeng Cai*. AApeptides as a New Class of Peptidomimetics to Regulate Protein-Protein Interactions. Link. Protein Interactions, 2012, ISBN: 978-953-51-0244-1.
